How do you tell the difference between acrylic and glass walls of an aquarium? Can you drill through acrylic?

Answers:
One is certainly the price tag, acrylic is far more expensive in most cases. Secondly is the feel. Acrylic is plastic and for lack of a better way to put it feels like plastic. Glass will feel harder and colder as well. Another dead give away is the corners. Glass tanks are held together with silicone while acrylic tanks are bent to form seamless corners.

Either glass or acrylic can be drilled if handled correctly. Acrylic is far easier to drill.

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Acrylic scratches very easily. I've polished many tanks over the year, but glass holds up better, though I've re-caulked many of them too. You can drill through either, though for glass, special tools are needed.